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Objective: To develop a reproducible immortalized humanchondrocyte culture model for studying the regulation of chondrocyte functions relevant to arthritic diseases in adult humans.
2
Methods Immortalized humanchondrocytes were developed for studying responses to cytokines and prostaglandins.
3
Over-proliferation of humanchondrocytes may contributes to OA pathological process.
4
Interpretation: The biosynthetic activity of humanchondrocytes from osteoarthritic joints can be enhanced using selected compression regimes.
5
By radio-ligand binding experiments we have shown the existence of similar receptors on the surface of humanchondrocytes.
Usage of human chondrocytes in English
1
Methods Immortalized humanchondrocytes were developed for studying responses to cytokines and prostaglandins.
2
Over-proliferation of humanchondrocytes may contributes to OA pathological process.
3
Interpretation: The biosynthetic activity of humanchondrocytes from osteoarthritic joints can be enhanced using selected compression regimes.
4
By radio-ligand binding experiments we have shown the existence of similar receptors on the surface of humanchondrocytes.
5
This study dissected dedifferentiation mechanism of in vitro cultured humanchondrocytes by microarray analysis of gene expression changes.
6
Therefore, this study investigated the potential of three different coculture systems, combining human respiratory epithelial cells and humanchondrocytes.
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With this purpose in mind, humanchondrocytes were isolated and cultured using different culture procedures: monolayer, suspension and agar gel.
8
No such study is available for humanchondrocytes although young and old bovine and equine cartilage have been recently profiled.
9
Our objective is to investigate the effect of I-BET151 on a surgical mouse model of osteoarthritis (OA) and humanchondrocytes.